Many people who are new to hormone replacement therapy or athletes who use testosterone report changes in how they feel after the first few injections. These changes may include mood swings, headaches, or slight discomfort as hormone levels in the blood have not yet stabilized. The administration regimen often helps: a gradual increase or decrease in dosage, the right time for injections throughout the week, and coordination with sleep and activity schedules. In many manuals and reviews, experts advise not only choosing the optimal times for administration, but also paying attention to regularity in order to minimize fluctuations in hormone levels. For example, an article that explores this topic in more detail provides advice on the best time for testosterone injections, taking into account circadian rhythms and side effects . It is this comprehensive approach that can reduce unwanted reactions and make therapy more comfortable.